HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 385118Generated: October 30, 2026
Toluene → 4-Benzyloxy-3-chloro-5-methoxybenzoyl chloride
https://huagongshe.com/reaction/385118
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 6462801 | HCID 6462801 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Benzyloxy-3-chloro-5-methoxybenzoyl chloride | HCID 86668176 | — |
Reaction Steps
To 4-benzyloxy-3-chloro-5-methoxybenzoic acid (541 mg), toluene (5.4 mL), N,N-dimethylformamide (1 droplet) and thionyl chloride (0.16 mL) were added, and then the mixture was stirred at 60° C. for 16 hours. The solvent was distilled off under reduced pressure and then azeotroped with toluene to obtain the title compound (578 mg) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367843B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-60372128d1aa460f867f375b28a55aaf |
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| Source note | uspto-grants-2013_02 |
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