HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 385124Generated: October 29, 2026
Toluene → 3-Formyl-4-methoxy-5-trifluoromethylbenzoyl chloride
https://huagongshe.com/reaction/385124
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Formyl-4-methoxy-5-trifluoromethylbenzoic acid | HCID 86668149 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Formyl-4-methoxy-5-trifluoromethylbenzoyl chloride | HCID 86668178 | — |
Reaction Steps
To 3-formyl-4-methoxy-5-trifluoromethylbenzoic acid (2.05 g), toluene (20 mL), N,N-dimethylformamide (2 droplets) and thionyl chloride (0.70 mL) were added, and then the mixture was stirred at 60° C. for 6.5 hours. The solvent was distilled off under reduced pressure and then azeotroped with toluene to obtain the title compound (2.42 g) as a brown oily substance.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367843B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-361d9225f77b4c2fa808806f4aaf98f0 |
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| Source note | uspto-grants-2013_02 |
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