Thiazolidine → HCID 68108646, compound

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Reaction Steps

5-(1,1-dioxo-2,3-dihydro-1,3-benzothiazole-3-carbonyl)-2-methoxy-3-trifluoromethylbenzoic acid (277 mg) was dissolved in dichloromethane (3 mL), thiazolidine (0.10 mL) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (238 mg) were added to the solution, and then the mixture was stirred at room temperature for 19 hours. The solvent was distilled off under reduced pressure and 1N hydrochloric acid was added and then the mixture was extracted with ethyl acetate. The organic layer was washed with 1N hydrochloric acid, 1N sodium hydroxide and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure and the obtained residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1) to obtain the title compound (138 mg) as a colorless oily substance.

Provenance & Evidence