HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 385145Generated: October 29, 2026
Toluene → 3-Cyano-4-methoxy-5-trifluoromethoxybenzoyl chloride
https://huagongshe.com/reaction/385145
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Cyano-4-methoxy-5-trifluoromethoxybenzoic acid | HCID 68109115 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Cyano-4-methoxy-5-trifluoromethoxybenzoyl chloride | HCID 86668183 | — |
Reaction Steps
To 3-cyano-4-methoxy-5-trifluoromethoxybenzoic acid (500 mg), toluene (10 mL), N,N-dimethylformamide (3 droplets) and thionyl chloride (0.28 mL) were added, and then the mixture was stirred at 60° C. for 6 hours. The solvent was distilled off under reduced pressure and the obtained residue was azeotroped with toluene and used for the synthesis of (i).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367843B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-2da99fd23d9a4913a70de0d32358d53b |
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| Source note | uspto-grants-2013_02 |
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