Water → HCID 68108763, compound

Participants

Reaction Steps

Methyl 3-chloro-4-hydroxy-5-trifluoromethoxybenzoate (2.64 g) was dissolved in N,N-dimethylformamide (15 mL), and potassium carbonate (3.60 g) and dimethylsulfuric acid (1.64 mL) were added to the solution, and then the mixture was stirred at room temperature for 1 hour. Water was added to the reaction solution and the reaction mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure and the obtained residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=9:1) to obtain the title compound (1.70 g) as a colorless oily substance.

Provenance & Evidence