Lithium hydroxide, monohydrate → HCID 68108300, compound

Participants

Reaction Steps

Methyl 3-chloro-4-methoxy-5-trifluoromethoxybenzoate (1.70 g) was dissolved in tetrahydrofuran (12 mL) and water (6 mL), and lithium hydroxide monohydrate (1.00 g) was added to the solution, and the mixture was stirred at room temperature for 2 hours. The solvent was distilled off under reduced pressure and 1N hydrochloric acid was added, and then the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (1.51 g) as a colorless crystal.

Provenance & Evidence