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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 385245Generated: October 25, 2026

tert-Butyldimethylsilyl chloride → (R)-[1-[4-(Benzyloxy)-3-[[(tert-butyldimethylsilyl)oxy]methyl]phenyl]-2-bromoethoxy](tert-butyl)dimethylsilane

https://huagongshe.com/reaction/385245

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyldimethylsilyl chlorideHCID 28928—
Reactant(R)-1-[4-(Benzyloxy)-3-[[(tert-butyldimethylsilyl)oxy]methyl]phenyl]-2-bromoethanolHCID 58505102—
Product(R)-[1-[4-(Benzyloxy)-3-[[(tert-butyldimethylsilyl)oxy]methyl]phenyl]-2-bromoethoxy](tert-butyl)dimethylsilaneHCID 58505282—

Reaction Steps

The title compound was synthesized in a manner analogous to that described for Intermediate 5. Excess TBSCl and a higher reaction temperature were used.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08367829B2
Source datasetuspto-grants-2013_02
ORD IDord-43784abb7de3479ea9ebc8426c5fa5e5
Source noteuspto-grants-2013_02