HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → N-(3,4-Dichlorophenyl)-6,7-dihydro-5H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Ethyl 4-[(3,4-dichlorophenyl)amino]-5,7-dihydro-6H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidine-6-carboxylate | HCID 58116842 | — |
| Product | N-(3,4-Dichlorophenyl)-6,7-dihydro-5H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidin-4-amine | HCID 58116802 | 59% |
Reaction Steps
In analogy to Example 23A, ethyl 4-[(3,4-dichlorophenyl)amino]-5,7-dihydro-6H-pyrrolo[3′,4′:4,5]thieno[2,3-d]pyrimidine-6-carboxylate from Example 24A (324 mg, 0.79 mmol) was treated with aqueous potassium hydroxide solution to yield 157 mg (59%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524722B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-e822b1cbddab45f5a8568328a9478d0d |
| Source note | uspto-grants-2013_09 |