4-(5-Hydroxypent-1-yn-1-yl)benzoic acid → N-[[1,6-Diethyl-4-[(tetrahydro-2H-pyran-4-yl)amino]-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl]-4-(5-hydroxypent-1-yn-1-yl)benzamide

Participants

Role	Name	HCID	Charge
Reactant	4-(5-Hydroxypent-1-yn-1-yl)benzoic acid	HCID 57517583	—
Reactant	N-[[1,6-Diethyl-4-[(tetrahydro-2H-pyran-4-yl)amino]-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl]-3-(2-oxopropyl)benzamide	HCID 58505292	—
Product	N-[[1,6-Diethyl-4-[(tetrahydro-2H-pyran-4-yl)amino]-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl]-4-(5-hydroxypent-1-yn-1-yl)benzamide	HCID 58505289	—

Reaction Steps

The title compound was synthesized in a manner analogous to that described for Intermediate 29, using Intermediate 21 in place of 3-(2-oxopropyl)benzoic acid. ES/MS calcd. for C28H36N5O3+ 490.3. found m/z=490.4 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08367829B2
Source dataset	uspto-grants-2013_02
ORD ID	ord-6ea66787979c441daea28eb25f992d6f
Source note	uspto-grants-2013_02