HRID385276

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(Cc1cccc(C(=O)O)c1)NC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(OCc2ccccc2)c2[nH]c(=O)ccc12

HCID58505082

(R)-3-(2-((2-(8-(benzyloxy)-2-oxo-1,2-dihydroquinolin-5-yl)-2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-2-methylpropyl)benzoic acid

C35H44N2O5Si

结构：CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(CC(C)=O)c1

HCID58505292

未命名化合物

PRODUCTS

生成物

结构：CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(CC(C)(C)NC[C@H](O[Si](C)(C)C(C)(C)C)c2ccc(OCc3ccccc3)c3[nH]c(=O)ccc23)c1

HCID66989734

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in a manner analogous to that described for Intermediate 29, using Intermediate 50 in place of 3-(2-oxopropyl)benzoic acid. ES/MS calcd. for C51H68N7O5Si+ 886.5. found m/z=886.5 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d8306671d9254461a477e2966ccbaab7
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08367829B2
来源说明: uspto-grants-2013_02

反应 SMILES

[CH2:1]([N:3]1[C:7]2=[N:8][C:9]([CH2:33][CH3:34])=[C:10]([CH2:19][NH:20][C:21](=[O:32])C3C=CC=C(CC(=O)C)C=3)[C:11]([NH:12][CH:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[C:6]2[CH:5]=[N:4]1)[CH3:2].[CH2:35]([O:42][C:43]1[CH:44]=[CH:45][C:46]([C@@H:54]([O:70][Si:71]([C:74]([CH3:77])([CH3:76])[CH3:75])([CH3:73])[CH3:72])[CH2:55][NH:56][C:57]([CH3:69])([CH3:68])[CH2:58][C:59]2[CH:60]=[C:61]([CH:65]=[CH:66][CH:67]=2)C(O)=O)=[C:47]2[C:52]=1[NH:51][C:50](=[O:53])[CH:49]=[CH:48]2)[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[CH2:35]([O:42][C:43]1[CH:44]=[CH:45][C:46]([C@@H:54]([O:70][Si:71]([C:74]([CH3:76])([CH3:77])[CH3:75])([CH3:72])[CH3:73])[CH2:55][NH:56][C:57]([CH3:69])([CH3:68])[CH2:58][C:59]2[CH:60]=[C:61]([CH:65]=[CH:66][CH:67]=2)[C:21]([NH:20][CH2:19][C:10]2[C:11]([NH:12][CH:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[C:6]3[CH:5]=[N:4][N:3]([CH2:1][CH3:2])[C:7]3=[N:8][C:9]=2[CH2:33][CH3:34])=[O:32])=[C:47]2[C:52]=1[NH:51][C:50](=[O:53])[CH:49]=[CH:48]2)[C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1