(R)-3-(2-((2-(8-(benzyloxy)-2-oxo-1,2-dihydroquinolin-5-yl)-2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-2-methylpropyl)benzoic acid → (R)-3-[2-[[2-[8-(Benzyloxy)-2-oxo-1,2-dihydroquinolin-5-yl]-2-[(tert-butyldimethylsilyl)oxy]ethyl]amino]-2-methylpropyl]-N-[[1,6-diethyl-4-[(tetrahydro-2H-pyran-4-yl)amino]-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl]benzamide
Reaction equation
[CH2:1]([N:3]1[C:7]2=[N:8][C:9]([CH2:33][CH3:34])=[C:10]([CH2:19][NH:20][C:21](=[O:32])C3C=CC=C(CC(=O)C)C=3)[C:11]([NH:12][CH:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[C:6]2[CH:5]=[N:4]1)[CH3:2].[CH2:35]([O:42][C:43]1[CH:44]=[CH:45][C:46]([C@@H:54]([O:70][Si:71]([C:74]([CH3:77])([CH3:76])[CH3:75])([CH3:73])[CH3:72])[CH2:55][NH:56][C:57]([CH3:69])([CH3:68])[CH2:58][C:59]2[CH:60]=[C:61]([CH:65]=[CH:66][CH:67]=2)C(O)=O)=[C:47]2[C:52]=1[NH:51][C:50](=[O:53])[CH:49]=[CH:48]2)[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[CH2:35]([O:42][C:43]1[CH:44]=[CH:45][C:46]([C@@H:54]([O:70][Si:71]([C:74]([CH3:76])([CH3:77])[CH3:75])([CH3:72])[CH3:73])[CH2:55][NH:56][C:57]([CH3:69])([CH3:68])[CH2:58][C:59]2[CH:60]=[C:61]([CH:65]=[CH:66][CH:67]=2)[C:21]([NH:20][CH2:19][C:10]2[C:11]([NH:12][CH:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[C:6]3[CH:5]=[N:4][N:3]([CH2:1][CH3:2])[C:7]3=[N:8][C:9]=2[CH2:33][CH3:34])=[O:32])=[C:47]2[C:52]=1[NH:51][C:50](=[O:53])[CH:49]=[CH:48]2)[C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1Participants
3
Reactant 2
Product 1
Procedure
The title compound was synthesized in a manner analogous to that described for Intermediate 29, using Intermediate 50 in place of 3-(2-oxopropyl)benzoic acid. ES/MS calcd. for C51H68N7O5Si+ 886.5. found m/z=886.5 (M+H)+.
Sources & evidence
- ORD record
- ord-d8306671d9254461a477e2966ccbaab7
- Source dataset
- uspto-grants-2013_02
- Patent number
- US08367829B2
Reaction notes
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