HRID385278

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：[N-]=[N+]=NC[C@H](O)c1ccc(OCc2ccccc2)c2[nH]c(=O)ccc12

HCID58505170

未命名化合物

结构：CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(CC(C)(C)NC[C@H](O[Si](C)(C)C(C)(C)C)c2ccc(OCc3ccccc3)c3[nH]c(=O)ccc23)c1

HCID66989734

未命名化合物

PRODUCTS

生成物

结构：CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)c1cccc(CC(C)(C)NC[C@H](O)c2ccc(OCc3ccccc3)c3[nH]c(=O)ccc23)c1

HCID66990019

(R)-3-[2-[[2-[8-(Benzyloxy)-2-oxo-1,2-dihydroquinolin-5-yl]-2-hydroxyethyl]amino]-2-methylpropyl]-N-[[1,6-diethyl-4-[(tetra hydro-2H-pyran-4-yl)amino]-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl]benzamide

C45H53N7O5

PROCEDURE

实验过程

The title compound was synthesized in a manner analogous to that described for Intermediate 3, using Intermediate 52 as a substrate. ES/MS calcd. for C45H54N7O5+ 772.4. found m/z=772.4 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-93d82d4961284cdb87f022f8e62c8a69
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08367829B2
来源说明: uspto-grants-2013_02

反应 SMILES

N(C[C@@H](C1C=CC(OCC2C=CC=CC=2)=C2C=1C=CC(=O)N2)O)=[N+]=[N-].[CH2:26]([O:33][C:34]1[CH:35]=[CH:36][C:37]([C@@H:45]([O:82][Si](C(C)(C)C)(C)C)[CH2:46][NH:47][C:48]([CH3:81])([CH3:80])[CH2:49][C:50]2[CH:51]=[C:52]([CH:77]=[CH:78][CH:79]=2)[C:53]([NH:55][CH2:56][C:57]2[C:58]([NH:70][CH:71]3[CH2:76][CH2:75][O:74][CH2:73][CH2:72]3)=[C:59]3[CH:67]=[N:66][N:65]([CH2:68][CH3:69])[C:60]3=[N:61][C:62]=2[CH2:63][CH3:64])=[O:54])=[C:38]2[C:43]=1[NH:42][C:41](=[O:44])[CH:40]=[CH:39]2)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH2:26]([O:33][C:34]1[CH:35]=[CH:36][C:37]([C@@H:45]([OH:82])[CH2:46][NH:47][C:48]([CH3:80])([CH3:81])[CH2:49][C:50]2[CH:51]=[C:52]([CH:77]=[CH:78][CH:79]=2)[C:53]([NH:55][CH2:56][C:57]2[C:58]([NH:70][CH:71]3[CH2:72][CH2:73][O:74][CH2:75][CH2:76]3)=[C:59]3[CH:67]=[N:66][N:65]([CH2:68][CH3:69])[C:60]3=[N:61][C:62]=2[CH2:63][CH3:64])=[O:54])=[C:38]2[C:43]=1[NH:42][C:41](=[O:44])[CH:40]=[CH:39]2)[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1