HRID385279

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)CCCCCCCBr

HCID58017300

未命名化合物

结构：CC(C)(C)[Si](C)(C)O[C@@H](CNCCCC#Cc1ccc(NC(=O)C(F)(F)F)cc1)c1ccc(O)c2[nH]c(=O)ccc12

HCID58505275

未命名化合物

PRODUCTS

生成物

结构：CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)CCCCCCCNC[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(O)c2[nH]c(=O)ccc12

HCID66990001

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in a manner analogous to that described for Intermediate 37, using Intermediate 33 in place of Intermediate 26. ES/MS calcd. for C41H64N7O5Si 762.5. found m/z=762.5 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-082bf0a2189a44a5bf93e1c7743a73e0
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08367829B2
来源说明: uspto-grants-2013_02

反应 SMILES

[Si:1]([O:8][C@H:9]([C:30]1[CH:39]=[CH:38][C:37]([OH:40])=[C:36]2[C:31]=1[CH:32]=[CH:33][C:34](=[O:41])[NH:35]2)[CH2:10][NH:11][CH2:12][CH2:13]CC#CC1C=CC(NC(=O)C(F)(F)F)=CC=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].BrCC[CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][C:50]([NH:52][CH2:53][C:54]1[C:55]([NH:67][CH:68]2[CH2:73][CH2:72][O:71][CH2:70][CH2:69]2)=[C:56]2[CH:64]=[N:63][N:62]([CH2:65][CH3:66])[C:57]2=[N:58][C:59]=1[CH2:60][CH3:61])=[O:51]>>[Si:1]([O:8][C@H:9]([C:30]1[CH:39]=[CH:38][C:37]([OH:40])=[C:36]2[C:31]=1[CH:32]=[CH:33][C:34](=[O:41])[NH:35]2)[CH2:10][NH:11][CH2:12][CH2:13][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][C:50]([NH:52][CH2:53][C:54]1[C:55]([NH:67][CH:68]2[CH2:69][CH2:70][O:71][CH2:72][CH2:73]2)=[C:56]2[CH:64]=[N:63][N:62]([CH2:65][CH3:66])[C:57]2=[N:58][C:59]=1[CH2:60][CH3:61])=[O:51])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:2])[CH3:3]