HRID385280

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)[Si](C)(C)O[C@@H](CNCCCC#Cc1ccc(NC(=O)C(F)(F)F)cc1)c1ccc(O)c2[nH]c(=O)ccc12

HCID58505275

未命名化合物

结构：CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)Nc1ccc(C#CCCCBr)cc1

HCID58505295

未命名化合物

PRODUCTS

生成物

结构：CCc1nc2c(cnn2CC)c(NC2CCOCC2)c1CNC(=O)Nc1ccc(C#CCCCNC[C@H](O[Si](C)(C)C(C)(C)C)c2ccc(O)c3[nH]c(=O)ccc23)cc1

HCID58505291

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in a manner analogous to that described for Intermediate 37, using Intermediate 35 in place of Intermediate 26. ES/MS calcd. for C45H61N8O5Si+ 821.5. found m/z=821.6 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-345e4582e21f463dbdb503e8dcef68b2
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08367829B2
来源说明: uspto-grants-2013_02

反应 SMILES

[Si:1]([O:8][C@H:9]([C:30]1[CH:39]=[CH:38][C:37]([OH:40])=[C:36]2[C:31]=1[CH:32]=[CH:33][C:34](=[O:41])[NH:35]2)[CH2:10][NH:11]CCCC#CC1C=CC(NC(=O)C(F)(F)F)=CC=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].Br[CH2:43][CH2:44][CH2:45][C:46]#[C:47][C:48]1[CH:53]=[CH:52][C:51]([NH:54][C:55]([NH:57][CH2:58][C:59]2[C:60]([NH:72][CH:73]3[CH2:78][CH2:77][O:76][CH2:75][CH2:74]3)=[C:61]3[CH:69]=[N:68][N:67]([CH2:70][CH3:71])[C:62]3=[N:63][C:64]=2[CH2:65][CH3:66])=[O:56])=[CH:50][CH:49]=1>>[Si:1]([O:8][C@H:9]([C:30]1[CH:39]=[CH:38][C:37]([OH:40])=[C:36]2[C:31]=1[CH:32]=[CH:33][C:34](=[O:41])[NH:35]2)[CH2:10][NH:11][CH2:43][CH2:44][CH2:45][C:46]#[C:47][C:48]1[CH:53]=[CH:52][C:51]([NH:54][C:55]([NH:57][CH2:58][C:59]2[C:60]([NH:72][CH:73]3[CH2:74][CH2:75][O:76][CH2:77][CH2:78]3)=[C:61]3[CH:69]=[N:68][N:67]([CH2:70][CH3:71])[C:62]3=[N:63][C:64]=2[CH2:65][CH3:66])=[O:56])=[CH:50][CH:49]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:2])[CH3:3]