(R)-5-(2-Amino-1-((tert-butyldimethylsilyl)oxy)ethyl)-8-hydroxyquinolin-2(1H)-one → (R)-N-[[1,6-Diethyl-4-[(tetrahydro-2H-pyran-4-yl)amino]-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl]-3-[2-[[2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl]amino]-2-methylpropyl]benzamide
Reaction equation
NC[C@@H](C1C=CC(O)=C2C=1C=CC(=O)N2)O[Si](C(C)(C)C)(C)C.C([O:31][C:32]1[CH:37]=[CH:36][C:35]([C@@H:38]([OH:75])[CH2:39][NH:40][C:41]([CH3:74])([CH3:73])[CH2:42][C:43]2[CH:44]=[C:45]([CH:70]=[CH:71][CH:72]=2)[C:46]([NH:48][CH2:49][C:50]2[C:51]([NH:63][CH:64]3[CH2:69][CH2:68][O:67][CH2:66][CH2:65]3)=[C:52]3[CH:60]=[N:59][N:58]([CH2:61][CH3:62])[C:53]3=[N:54][C:55]=2[CH2:56][CH3:57])=[O:47])=[CH:34][C:33]=1[CH2:76][OH:77])C1C=CC=CC=1>>[CH2:61]([N:58]1[C:53]2=[N:54][C:55]([CH2:56][CH3:57])=[C:50]([CH2:49][NH:48][C:46](=[O:47])[C:45]3[CH:70]=[CH:71][CH:72]=[C:43]([CH2:42][C:41]([NH:40][CH2:39][C@H:38]([OH:75])[C:35]4[CH:36]=[CH:37][C:32]([OH:31])=[C:33]([CH2:76][OH:77])[CH:34]=4)([CH3:74])[CH3:73])[CH:44]=3)[C:51]([NH:63][CH:64]3[CH2:65][CH2:66][O:67][CH2:68][CH2:69]3)=[C:52]2[CH:60]=[N:59]1)[CH3:62]Participants
3
Reactant 2
Product 1
Procedure
The title compound was synthesized in a manner analogous to that described in Intermediate 2, using Intermediate 53 as substrate.
Sources & evidence
- ORD record
- ord-801702d581d44b9fa8c6663719d26f9d
- Source dataset
- uspto-grants-2013_02
- Patent number
- US08367829B2
Reaction notes
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