(R)-5-(2-Amino-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one → (R)-N-[[1,6-diethyl-4-[(tetrahydro-2H-pyran-4-yl)amino]-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl]-4-[[[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl]ethyl]amino]methyl]benzamide

Participants

Role	Name	HCID	Charge
Reactant	(R)-5-(2-Amino-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one	HCID 24996153	—
Reactant	N-[[1,6-Diethyl-4-[(tetrahydro-2H-pyran-4-yl)amino]-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl]-4-formylbenzamide	HCID 58505284	—
Product	(R)-N-[[1,6-diethyl-4-[(tetrahydro-2H-pyran-4-yl)amino]-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl]-4-[[[2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl]ethyl]amino]methyl]benzamide	HCID 54588808	—

Reaction Steps

The title compound was synthesized in a manner analogous to that described for Intermediate 43, using Intermediate 4 in place of Intermediate 8 and Intermediate 31 in place of Intermediate 29.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08367829B2
Source dataset	uspto-grants-2013_02
ORD ID	ord-1f9c991855354748b2d86383b35675e8
Source note	uspto-grants-2013_02