HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Fluorobenzyl)-1H-indazol-5-amine → Ethyl 4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}-5,7-dihydro-6H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidine-6-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Fluorobenzyl)-1H-indazol-5-amine | HCID 7147073 | — |
| Reactant | Ethyl12-chloro-7-thia-4,9,11-triazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene-4-carboxylate | HCID 58116864 | — |
| Product | Ethyl 4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}-5,7-dihydro-6H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidine-6-carboxylate | HCID 58116971 | — |
Reaction Steps
In analogy to Example 22A, ethyl 4-chloro-5,7-dihydro-6H-pyrrolo[3′,4′:4,5]thieno[2,3-d]pyrimidine-6-carboxylate from Example 21A (100 mg, 0.35 mmol) and 1-(3-fluorobenzyl)-1H-indazol-5-amine from Example 8A (89 mg, 0.37 mmol) were reacted to the title compound to yield 120 mg (68%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524722B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-df715e35007a4f3783a79408c4a6f9db |
| Source note | uspto-grants-2013_09 |