3-Chloro-4-(2-pyridylmethoxy)aniline → tert-Butyl 4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-5,8-dihydrothieno[2,3-b:5,4-c']dipyridine-7(6H)-carboxylate

Participants

Reaction Steps

In analogy to Example 54A, the title compound was synthesized from tert-butyl 4-chloro-3-cyano-5,8-dihydrothieno[2,3-b:5,4-c′]dipyridine-7(6H)-carboxylate from Example 53A (190 mg, 0.54 mmol) and 3-chloro-4-(pyridin-2-ylmethoxy)aniline from Example 6A (127 mg, 0.54 mmol) to yield 215 mg (88% purity, 64% yield), which were used without further purification.

Provenance & Evidence