Ethyl 2-(3-(cyclopropylmethoxy)-4-nitrophenyl)acetate → Ethyl 2-(4-amino-3-(cyclopropylmethoxy)phenyl)acetate

Participants

Reaction Steps

To a stirred solution of ethyl 2-(3-(cyclopropylmethoxy)-4-nitrophenyl)acetate (10 g), in dry MeOH (100 mL) was added Pd(OH)2 (2 g). The mixture was hydrogenated under a H2 atmosphere for 6 h at room temperature. The reaction mixture was filtered through a pad of Celite™, washing with MeOH. The combined filtrates were concentrated under reduced pressure to yield 7.5 g of the desired product as an oil.

Provenance & Evidence