HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Pyridin-2-ylmethyl)-1H-indazol-5-amine → N-[1-(Pyridin-2-ylmethyl)-1H-indazol-5-yl]-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]-pyrimidin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Pyridin-2-ylmethyl)-1H-indazol-5-amine | HCID 21952366 | — |
| Reactant | tert-Butyl 4-chloro-5,6-dihydropyrido(4',3':4,5)thieno(2,3-d)pyrimidine-7(8H)-carboxylate | HCID 49788563 | — |
| Product | N-[1-(Pyridin-2-ylmethyl)-1H-indazol-5-yl]-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]-pyrimidin-4-amine | HCID 58116989 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 12A from tert-butyl 4-chloro-5,8-dihydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidine-7(6H)-carboxylate from Example 11A (4.84 g, 14.5 mmol) and 1-(pyridin-2-ylmethyl)-1H-indazol-5-amine from Example 61A (3.50 g, 15.6 mmol) to yield 4.39 g (71%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524722B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-19577c89ba2a4755b76ed050067ed4ca |
| Source note | uspto-grants-2013_09 |