Potassium Hydroxide → Tert-butyl (3,4-dichloro-5-hydroxyphenyl)carbamate

Participants

Role	Name	HCID	Charge
Reactant	Potassium Hydroxide	HCID 14797	—
Reactant	N-(tert-Butoxycarbonyl)-3,4,5-trichloroaniline	HCID 18929852	—
Product	Tert-butyl (3,4-dichloro-5-hydroxyphenyl)carbamate	HCID 58116863	—

Reaction Conditions

Temperature	90 °C

Reaction Steps

In analogy to Example 63A, tert-butyl(3,4,5-trichlorophenyl)carbamate from Example 66A (3.98 g, 13.4 mmol) was reacted with potassium hydroxide (1.77 g, 26.8 mmol). The reaction mixture was heated to 80° C. overnight and subsequently to 90° C. for 3 h. The product was isolated by preparative HPLC to yield 760 mg (20%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08524722B2
Source dataset	uspto-grants-2013_09
ORD ID	ord-2834e6463a5c4394b92d7a553004b9d3
Source note	uspto-grants-2013_09