Hydrogen chloride-ethyl acetate → HCID 68929017, compound

Participants

Reaction Steps

To a solution of 0.50 g of 1-tert-butyl 4-ethyl 4-(3-(2-oxo-1,7-naphthyridin-1(2H)-yl)propyl)piperidine-1,4-dicarboxylate in 3 mL of ethanol, 3.0 mL of a 4.0 mol/L hydrogen chloride/ethyl acetate solution was added, and the mixture was stirred at room temperature for 1 hour. Thereto was added 2.0 mL of a 4.0 mol/L hydrogen chloride/ethyl acetate solution, and the mixture was stirred at room temperature for 1 hour. The solid was filtered off to obtain 0.29 g of ethyl 4-(3-(2-oxo-1,7-naphthyridin-1(2H)-yl)propyl)piperidine-4-carboxylate hydrochloride as a light yellow solid.

Provenance & Evidence