tert-Butyl 4-chloro-5,6-dihydropyrido(4',3':4,5)thieno(2,3-d)pyrimidine-7(8H)-carboxylate → 2,3-Dichloro-5-(5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride

Participants

Reaction Steps

The title compound was prepared in analogy to Example 65A from tert-butyl 4-chloro-5,8-dihydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidine-7(6H)-carboxylate from Example 11A (300 mg, 0.92 mmol) and 5-amino-2,3-dichlorophenol hydrochloride from Example 68A (296 mg, 1.38 mmol) to yield 395 mg (99%).

Provenance & Evidence