3,4-Dichloroaniline → HCID 66849855, compound

HRID 38560Notes

Reaction equation

HRID 38560 reaction equation
Cl[C:2]1[C:3]2[C:10]3[CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][CH2:14][C:9]=3[S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[Cl:22][C:23]1[CH:24]=[C:25]([CH:27]=[CH:28][C:29]=1[Cl:30])[NH2:26]>>[Cl:22][C:23]1[CH:24]=[C:25]([NH:26][C:2]2[C:3]3[C:10]4[CH2:11][NH:12][CH2:13][CH2:14][C:9]=4[S:8][C:4]=3[N:5]=[CH:6][N:7]=2)[CH:27]=[CH:28][C:29]=1[Cl:30]

Participants

3

Reactant 2

HCID 72573,4-DichloroanilineHCID 58116884HCID 58116884, compound

Product 1

HCID 66849855HCID 66849855, compound

Procedure

The title compound was prepared in analogy to Example 12A from tert-butyl 4-chloro-7,8-dihydropyrido[3′,4′:4,5]thieno[2,3-d]pyrimidine-6(5H)-carboxylate from Example 75A (122 mg, 0.37 mmol) and 3,4-dichloroaniline (64 mg, 0.39 mmol) to yield 127 mg (91%).

Workup

  1. customto yield 127 mg (91%)

Sources & evidence

ORD record
ord-13930419584e4c51b19968abb3f6b7a3
Source dataset
uspto-grants-2013_09
Patent number
US08524722B2

Reaction notes

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