Hydrogen chloride-ethyl acetate → HCID 68930834, compound

Participants

Reaction Steps

To a solution of 0.16 g of 1-(2-(4-((3-fluoro-4-methylbenzyl)amino)piperidin-1-yl)ethyl)-1,7-naphthyridin-2(1H)-one in 3 mL of ethyl acetate, 5 mL of a 4.0 mol/L hydrogen chloride/ethyl acetate solution was added at room temperature. Thereto was added 2 mL of ethyl acetate, the mixture was stirred at the same temperature for 10 minutes, and the solvent was distilled off under reduced pressure. Ethyl acetate was added to the resultant residue, and the solid was filtered off to obtain 0.18 g of 1-(2-(4-((3-fluoro-4-methylbenzyl)amino)piperidin-1-yl)ethyl)-1,7-naphthyridin-2(1H)-one hydrochloride as a light yellow solid.

Provenance & Evidence