Hydrogen chloride-ethyl acetate → HCID 68928882, compound

Participants

Reaction Steps

To 0.69 g of tert-butyl (2,3-dihydro-1,4-benzodioxin-6-ylmethyl)(1-(2-(2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate, 25 mL of a 4 mol/L hydrogen chloride/ethyl acetate solution was added, and the mixture was stirred at room temperature for 42 hours. The solvent was distilled off under reduced pressure, a mixed solution of ethyl acetate and ethanol (5:1) was added to the resultant residue, and the solid was filtered off to obtain 0.59 g of 1-(2-(4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-1,5-naphthyridin-2(1H)-one hydrochloride as a light yellow solid.

Provenance & Evidence