Ethyl Acetate → HCID 68924696, compound

Participants

Reaction Steps

To a solution of 36 mg of 1-(2-(4-((2,3-dihydro (1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)piperidin-1-yl)ethyl)-7-cyano-1,5-naphthyridin-2(1H)-one in 5 mL of acetic acid, 0.5 mL of a 4 mol/L hydrogen chloride/ethyl acetate and 5 mL of ethyl acetate were added, and the mixture was stirred at room temperature for 10 minutes. The solvent was distilled off under reduced pressure to obtain 44 mg of 1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)piperidin-1-yl)ethyl)-7-cyano-1,5-naphthyridin-2(1H)-one hydrochloride as a white solid.

Provenance & Evidence