Hydrochloric Acid → HCID 68926892, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.48 g of tert-butyl (2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)(1-(2-(7-fluoro-6-methyl-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate in 4.7 mL of isopropyl alcohol, 0.44 mL of concentrated hydrochloric acid was added, the temperature was increased to 60° C. and the mixture was stirred for 3 hours. The reaction mixture was cooled to room temperature, and the solid was filtered off to obtain 0.33 g of 1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)piperidin-1-yl)ethyl)-7-fluoro-6-methyl-1,5-naphthyridin-2(1H)-one hydrochloride as a white solid.

Provenance & Evidence