Ethanol hydrochloride → HCID 68926984, compound

Participants

Reaction Steps

To a solution of 0.095 g of 7-amino-1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)piperidin-1-yl)ethyl)-1,5-naphthyridin-2(1H)-one in 3 mL of ethanol and 2 mL of ethyl acetate, 4 mL of a 2 mol/L hydrogen chloride/ethanol solution was added at room temperature, and the mixture was stirred at room temperature for 20 minutes, and the solvent was distilled off under reduced pressure. To the residue, 8 mL of diethyl ether was added, the residue was suspended therein, and the solid was filtered off to obtain 0.41 g of 7-amino-1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)piperidin-1-yl)ethyl)-1,5-naphthyridin-2(1H)-one hydrochloride as a yellow solid.

Provenance & Evidence