HRID38570

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7147073

1-(3-FLUOROBENZYL)-1H-INDAZOL-5-AMINE

C14H12FN3

结构：CC(C)(C)OC(=O)N1CCc2c(sc3ncc(C#N)c(Cl)c23)C1

HCID58116935

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCc2c(sc3ncc(C#N)c(Nc4ccc5c(cnn5Cc5cccc(F)c5)c4)c23)C1

HCID58116903

未命名化合物

PROCEDURE

实验过程

In analogy to Example 54A, the title compound was synthesized from 1-(3-fluorobenzyl)-1H-indazol-5-amine from Example 8A (138 mg, 0.57 mmol) and tert-butyl 4-chloro-3-cyano-5,8-dihydrothieno[2,3-b:5,4-c′]dipyridine-7(6H)-carboxylate (200 mg, 0.57 mmol) from Example 53A to yield 234 mg (74%).

WORKUP

后处理

customto yield 234 mg (74%)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-08d53609cbe642179b61832c5b9f1a0c
来源数据集: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08524722B2
来源说明: uspto-grants-2013_09

反应 SMILES

[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([NH2:15])=[CH:12][CH:13]=2)[CH:8]=[N:7]1.Cl[C:20]1[C:25]([C:26]#[N:27])=[CH:24][N:23]=[C:22]2[S:28][C:29]3[CH2:30][N:31]([C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:32][CH2:33][C:34]=3[C:21]=12>>[C:26]([C:25]1[C:20]([NH:15][C:11]2[CH:10]=[C:9]3[C:14](=[CH:13][CH:12]=2)[N:6]([CH2:5][C:4]2[CH:16]=[CH:17][CH:18]=[C:2]([F:1])[CH:3]=2)[N:7]=[CH:8]3)=[C:21]2[C:34]3[CH2:33][CH2:32][N:31]([C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:30][C:29]=3[S:28][C:22]2=[N:23][CH:24]=1)#[N:27]