HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 385714Generated: October 25, 2026
Sodium Carbonate → 5-[4-(Methylsulfonyl)phenyl]-2-nitrothiophene-3-carboxamide
https://huagongshe.com/reaction/385714
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-(4-Methanesulfonylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 2759530 | — |
| Reactant | 5-Bromo-2-nitrothiophene-3-carboxamide | HCID 53402948 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-[4-(Methylsulfonyl)phenyl]-2-nitrothiophene-3-carboxamide | HCID 59525765 | — |
Reaction Steps
5-Bromo-2-nitrothiophene-3-carboxamide (1 g, 3.98 mmol), 4,4,5,5-tetramethyl-2-[4-(methylsulfonyl)phenyl]-1,3,2-dioxaborolane (1.236 g, 4.38 mmol) and tetrakis(triphenylphosphine)palladium(0) (0.230 g, 0.199 mmol) were taken up in THF (14 mL)/2 N Na2CO3 (6 mL) The reaction was stirred at 80° C. overnight. Room temperature was attained and the resulting precipitate was collected by filtration, washed with water and triturated in EtOH to give the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08367706B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-4a2d4524a4314dec81cb80128f2914bc |
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| Source note | uspto-grants-2013_02 |
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