5-[4-(Methylsulfonyl)phenyl]-2-nitrothiophene-3-carboxamide → 2-Amino-5-[4-(methylsulfonyl)phenyl]thiophene-3-carboxamide

Participants

Reaction Steps

Nitro reduction, Method A: 5-[4-(Methylsulfonyl)phenyl]-2-nitrothiophene-3-carboxamide (0.96 g, 2.94 mmol) and Pt/C, doped with V (0.191 g, 0.029 mmol) were stirred in MeOH (60 mL) at room temperature under a balloon of H2 for 90 minutes. The catalyst was removed by filtering through Celite, which was subsequently washed with DMF. The solvent was removed in vacuo and the residue triturated in EtOH to give the title compound as a dark brown solid.

Provenance & Evidence