4-Acetylphenylboronic acid → 5-(4-Acetylphenyl)-2-nitrothiophene-3-carboxamide

HRID 385725Notes

Reaction equation

HRID 385725 reaction equation
Br[C:2]1[S:6][C:5]([N+:7]([O-:9])=[O:8])=[C:4]([C:10]([NH2:12])=[O:11])[CH:3]=1.[C:13]([C:16]1[CH:21]=[CH:20][C:19](B(O)O)=[CH:18][CH:17]=1)(=[O:15])[CH3:14]>>[C:13]([C:16]1[CH:21]=[CH:20][C:19]([C:2]2[S:6][C:5]([N+:7]([O-:9])=[O:8])=[C:4]([C:10]([NH2:12])=[O:11])[CH:3]=2)=[CH:18][CH:17]=1)(=[O:15])[CH3:14]

Participants

3

Reactant 2

HCID 37021224-Acetylphenylboronic acidHCID 534029485-Bromo-2-nitrothiophene-3-carboxamide3×

Product 1

HCID 595260295-(4-Acetylphenyl)-2-nitrothiophene-3-carboxamide

Procedure

The title compound was prepared according to the general procedure in Intermediate 10 Step 5 using 5-bromo-2-nitrothiophene-3-carboxamide (Intermediate 10, Step 4) (0.5 g, 1.992 mmol) and (4-acetylphenyl)boronic acid (0.392 g, 2.390 mmol) as the starting materials.

Sources & evidence

ORD record
ord-2b0bbeff10214232a339aab868ec789e
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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