5-Bromo-2-nitrothiophene-3-carboxamide → 2-Amino-5-[4-(1-hydroxyethyl)phenyl]thiophene-3-carboxamide

HRID 385727Notes

Reaction equation

HRID 385727 reaction equation
BrC1SC([N+]([O-])=O)=C(C(N)=O)C=1.[OH:13][CH:14]([C:16]1[CH:21]=[CH:20][C:19]([C:22]2[S:26][C:25]([N+:27]([O-])=O)=[C:24]([C:30]([NH2:32])=[O:31])[CH:23]=2)=[CH:18][CH:17]=1)[CH3:15]>>[NH2:27][C:25]1[S:26][C:22]([C:19]2[CH:20]=[CH:21][C:16]([CH:14]([OH:13])[CH3:15])=[CH:17][CH:18]=2)=[CH:23][C:24]=1[C:30]([NH2:32])=[O:31]

Participants

3

Reactant 2

HCID 534029485-Bromo-2-nitrothiophene-3-carboxamideHCID 595257315-[4-(1-Hydroxyethyl)phenyl]-2-nitrothiophene-3-carboxamide

Product 1

HCID 595260932-Amino-5-[4-(1-hydroxyethyl)phenyl]thiophene-3-carboxamide

Procedure

The title compound was prepared according to the general procedure in Intermediate 10 Step 6 using 5-[4-(1-hydroxyethyl)phenyl]-2-nitrothiophene-3-carboxamide (198 mg, 0.68 mmol) as the starting material.

Sources & evidence

ORD record
ord-40e56a20ccc94a4bb59595fb161f3c06
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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