5-Bromo-2-nitrothiophene-3-carboxamide → HCID 59526221, compound

HRID 385732Notes

Reaction equation

HRID 385732 reaction equation
Br[C:2]1[S:6][C:5]([N+:7]([O-:9])=[O:8])=[C:4]([C:10]([NH2:12])=[O:11])[CH:3]=1.[F:13][C:14]1[CH:19]=[C:18]([N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)[CH:17]=[C:16]([F:26])[C:15]=1B(O)O>>[F:26][C:16]1[CH:17]=[C:18]([N:20]2[CH2:21][CH2:22][O:23][CH2:24][CH2:25]2)[CH:19]=[C:14]([F:13])[C:15]=1[C:2]1[S:6][C:5]([N+:7]([O-:9])=[O:8])=[C:4]([C:10]([NH2:12])=[O:11])[CH:3]=1

Participants

3

Reactant 2

HCID 534029485-Bromo-2-nitrothiophene-3-carboxamide3×HCID 59525633HCID 59525633, compound

Product 1

HCID 59526221HCID 59526221, compound

Procedure

The title compound was prepared as described in Intermediate 10 Step 5 using 5-bromo-2-nitrothiophene-3-carboxamide (Intermediate 10 Step 4) (582 mg, 2.32 mmol) and (2,6-difluoro-4-morpholin-4-ylphenyl)boronic acid (TFA salt) (830 mg, 2.33 mmol) as starting materials.

Sources & evidence

ORD record
ord-cfe59601942a4a708c8d0ec0548da2d2
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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