Dimethylamine → HCID 59525931, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-[4-(dichloromethyl)-5-nitro-2-thienyl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,4-triazole (1.00 g, 2.44 mmol) and Me2NH (40% wt, 15.00 mL, 118 mmol) was stirred at 60° C. for 15 min. The reaction was cooled to room temperature, diluted with water, and extracted with CH2Cl2 (2×). The combined organic layers were dried (MgSO4), filtered, and evaporated. Purification of the crude residue by flash chromatography (0-50% EtOAc/hexanes) provided the title compound as a yellow solid.

Provenance & Evidence