Hydroxyamine hydrochloride → HCID 72315998, compound

Participants

Reaction Steps

2-Nitro-5-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,4-triazol-3-yl)thiophene-3-carbaldehyde (1.85 g, 5.22 mmol), NH2OH.HCl (381 mg, 5.48 mmol), and NaOAc (450 mg, 5.48 mmol) were combined in EtOH (30 mL) and stirred at room temperature for 2 h. The reaction was diluted with saturated NaHCO3 and extracted with EtOAc (2×). The combined organic layers were washed with brine, dried (MgSO4), filtered, and evaporated to afford the title compound as an orange solid (mixture of oxime E/Z isomers).

Provenance & Evidence