Hydrazine hydrate (1:1) → HCID 59525774, compound

Participants

Reaction Steps

To 2-nitro-5-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,4-triazol-3-yl)thiophene-3-carboxamide (600 mg, 1.62 mmol) in MeOH (25 mL) was added FeCl3 (13 mg, 0.081 mmol). The solution was heated to reflux, and hydrazine hydrate (65%, 0.364 ml, 4.87 mmol) was added. After stirring for 30 minutes at reflux, the mixture was cooled to room temperature, combined with MeOH and silica gel, and evaporated to dryness. Flash chromatography (dry load, 0-10% MeOH/EtOAc) afforded the title compound as a colorless solid.

Provenance & Evidence