2-Amino-5-(2-fluorophenyl)thiophene-3-carboxamide → 5-(2-Fluorophenyl)-2-{[6-(1-hydroxy-1-methylethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

HRID 385755Notes

Reaction equation

HRID 385755 reaction equation
Br[C:2]1[N:7]=[C:6]([C:8]([OH:11])([CH3:10])[CH3:9])[CH:5]=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][C:15]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[F:27])=[CH:16][C:17]=1[C:18]([NH2:20])=[O:19]>>[F:27][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[C:15]1[S:14][C:13]([NH:12][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([C:8]([OH:11])([CH3:10])[CH3:9])[N:7]=2)=[C:17]([C:18]([NH2:20])=[O:19])[CH:16]=1

Participants

3

Reactant 2

HCID 99646972-Amino-5-(2-fluorophenyl)thiophene-3-carboxamideHCID 227143012-(6-Bromopyridin-2-yl)propan-2-ol

Product 1

HCID 595259985-(2-Fluorophenyl)-2-{[6-(1-hydroxy-1-methylethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

Procedure

The title compound was prepared according to the general procedure in Example 1 using 2-(6-bromopyridin-2-yl)propan-2-ol (65 mg, 0.301 mmol) and 2-amino-5-(2-fluorophenyl)thiophene-3-carboxamide (72.5 mg, 0.307 mmol) as the starting materials.

Sources & evidence

ORD record
ord-ef09bd2c84804c07a85cd10cbd443ff0
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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