2-Amino-5-(2-fluorophenyl)thiophene-3-carboxamide → 5-(2-Fluorophenyl)-2-{[6-(morpholin-4-ylmethyl)pyridin-2-yl]-amino}thiophene-3-carboxamide

HRID 385760Notes

Reaction equation

HRID 385760 reaction equation
Br[C:2]1[N:7]=[C:6]([CH2:8][N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[CH:5]=[CH:4][CH:3]=1.[NH2:15][C:16]1[S:17][C:18]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[F:30])=[CH:19][C:20]=1[C:21]([NH2:23])=[O:22]>>[F:30][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[C:18]1[S:17][C:16]([NH:15][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([CH2:8][N:9]3[CH2:14][CH2:13][O:12][CH2:11][CH2:10]3)[N:7]=2)=[C:20]([C:21]([NH2:23])=[O:22])[CH:19]=1

Participants

3

Reactant 2

HCID 99646972-Amino-5-(2-fluorophenyl)thiophene-3-carboxamideHCID 234381474-((6-Bromopyridin-2-yl)methyl)morpholine

Product 1

HCID 251234875-(2-Fluorophenyl)-2-{[6-(morpholin-4-ylmethyl)pyridin-2-yl]-amino}thiophene-3-carboxamide

Procedure

The title compound was prepared according to the general procedure in Example 1 using 4-[(6-bromopyridin-2-yl)methyl]morpholine (53 mg, 0.206 mmol) and 2-amino-5-(2-fluorophenyl)thiophene-3-carboxamide (49.6 mg, 0.210 mmol) as the starting materials.

Sources & evidence

ORD record
ord-6059a1d4d56b4484ad473721d6b91c8d
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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