反应详情

To a solution of 5-(2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl)-2-((6-(hydroxymethyl)-2-pyridinyl)amino)-3-thiophenecarboxamide (Example 43) (513 mg, 1.28 mmol) in DMSO (83 ml) was added IBX polystyrene (2.9 g, 3.19 mmol). The reaction mixture was shaken at room temperature overnight. The reaction mixture was filtered and washed with DMSO (1 ml). Water was added to the eluent and a yellow precipitate was filtered, washed with water and dried in vacuo to afford the title compound.

1. filtrationThe reaction mixture was filtered
2. washwashed with DMSO (1 ml)
3. additionWater was added to the eluent
4. filtrationa yellow precipitate was filtered
5. washwashed with water
6. customdried in vacuo