8-(Phenylmethyl)-3-oxa-1,8-diazaspiro[4.5]decan-2-one → HCID 22975681, compound

HRID 385780Notes

Reaction equation

HRID 385780 reaction equation
C([N:8]1[CH2:18][CH2:17][C:11]2([NH:15][C:14](=[O:16])[O:13][CH2:12]2)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[NH:15]1[C:11]2([CH2:10][CH2:9][NH:8][CH2:18][CH2:17]2)[CH2:12][O:13][C:14]1=[O:16]

Participants

4

Reactant 1

HCID 577809438-(Phenylmethyl)-3-oxa-1,8-diazaspiro[4.5]decan-2-one

Product 1

HCID 22975681HCID 22975681, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a 250 ml round bottom flask was purged with nitrogen was added a solution of 8-benzyl-3-oxa-1,8-diazaspiro[4.5]decan-2-one (12.5 g, 51 mmol) in MeOH (70 ml) and 1.0 g of activated 10% Pd/C. The reaction mixture was placed under H2 (60 psi) for 5 h. The reaction mixture was filtered through celite, and the filtrate was evaporated under vacuum to yield the title compound as a solid.

Workup

  1. customTo a 250 ml round bottom flask was purged with nitrogen
  2. filtrationThe reaction mixture was filtered through celite
  3. customthe filtrate was evaporated under vacuum

Sources & evidence

ORD record
ord-e8f29e5ed3304a5e8542599a27d15dcd
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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