反应详情

To a 250 ml round bottom flask was purged with nitrogen was added a solution of 8-benzyl-3-oxa-1,8-diazaspiro[4.5]decan-2-one (12.5 g, 51 mmol) in MeOH (70 ml) and 1.0 g of activated 10% Pd/C. The reaction mixture was placed under H2 (60 psi) for 5 h. The reaction mixture was filtered through celite, and the filtrate was evaporated under vacuum to yield the title compound as a solid.

1. customTo a 250 ml round bottom flask was purged with nitrogen
2. filtrationThe reaction mixture was filtered through celite
3. customthe filtrate was evaporated under vacuum