5-(2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl)-2-((6-formyl-2-pyridinyl)amino)-3-thiophenecarboxamide → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[(2-oxo-3-oxa-1,8-diazaspiro[4.5]dec-8-yl)methyl]pyridin-2-yl}amino)thiophene-3-carboxamide

HRID 385781Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 385781
[F:1][C:2]1[CH:7]=[C:6]([C:8]([OH:11])([CH3:10])[CH3:9])[CH:5]=[CH:4][C:3]=1[C:12]1[S:16][C:15]([NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([CH:24]=O)[N:19]=2)=[C:14]([C:26]([NH2:28])=[O:27])[CH:13]=1.BrC1N=C(C[N:37]2[CH2:47][CH2:46][C:40]3([NH:44][C:43](=[O:45])[O:42][CH2:41]3)[CH2:39][CH2:38]2)C=CC=1>>[F:1][C:2]1[CH:7]=[C:6]([C:8]([OH:11])([CH3:10])[CH3:9])[CH:5]=[CH:4][C:3]=1[C:12]1[S:16][C:15]([NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][N:37]3[CH2:38][CH2:39][C:40]4([NH:44][C:43](=[O:45])[O:42][CH2:41]4)[CH2:46][CH2:47]3)[N:19]=2)=[C:14]([C:26]([NH2:28])=[O:27])[CH:13]=1

Komponenten

3

Edukt 2

HCID 595261585-(2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl)-2-((6-formyl-2-pyridinyl)amino)-3-thiophenecarboxamideHCID 866462638-[(6-Bromopyridin-2-yl)methyl]-3-oxa-1,8-diazaspiro[4.5]decan-2-one

Produkt 1

HCID 595260065-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[(2-oxo-3-oxa-1,8-diazaspiro[4.5]dec-8-yl)methyl]pyridin-2-yl}amino)thiophene-3-carboxamide

Versuchsvorschrift

The title compound was prepared according to Example 106 Step 2 using 5-(2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl)-2-((6-formyl-2-pyridinyl)amino)-3-thiophenecarboxamide (19.5 mg, 0.05 mmol) and 8-[(6-bromopyridin-2-yl)methyl]-3-oxa-1,8-diazaspiro[4.5]decan-2-one (7.6 mg, 0.05 mmol) as the starting materials.

Quellen und Nachweise

ORD-Eintrag
ord-fd1c3978ecd0441093df289799c1832b
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367706B2

Notizen zur Reaktion

Wird geladen…