HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(Aminomethyl)-1-methylpyrrolidin-2-one → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-({[(1-methyl-5-oxopyrrolidin-2-yl)methyl]amino}methyl)pyridin-2-yl]amino}thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(Aminomethyl)-1-methylpyrrolidin-2-one | HCID 22724560 | — |
| Reactant | 5-(2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl)-2-((6-formyl-2-pyridinyl)amino)-3-thiophenecarboxamide | HCID 59526158 | — |
| Product | 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-({[(1-methyl-5-oxopyrrolidin-2-yl)methyl]amino}methyl)pyridin-2-yl]amino}thiophene-3-carboxamide | HCID 59525952 | — |
Reaction Steps
The title compound was prepared as described in Example 106, Step 2 using the oxalate salt of 5-(aminomethyl)-1-methylpyrrolidin-2-one (21 mg, 0.096 mmol) and 5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(6-formylpyridin-2-yl)amino]thiophene-3-carboxamide (39 mg, 0.096 mmol) as starting materials.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08367706B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-9a31da31454042d697b9dd565d0e4575 |
| Source note | uspto-grants-2013_02 |