2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-hydroxy-1-morpholin-4-ylpropyl)pyridin-2-yl]amino}thiophene-3-carboxamide

Participants

Reaction Steps

The title compound was prepared as described in Example 1 using 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (150 mg, 0.510 mmol) and 1-(6-bromopyridin-2-yl)-1-morpholin-4-ylpropan-2-ol (168 mg, 0.510 mmol) as starting materials. 1H NMR (600 MHz, d6-DMSO): δ 11.96 (s, 1H), 7.84 (s, 1H), 7.81 (s, 1H), 7.66 (t, 1H), 7.54 (m, 1H), 7.36 (s, 1H), 7.32 (d, 1H), 7.31 (s, 1H), 7.95 (d, 1H), 6.78 (d, 1H), 5.13 (s, 1H), 4.55 (m, 1H), 4.18 (s, 1H), 3.54 (m, 4H), 3.31 (d, 1H), 2.61 (m, 2H), 2.33 (m, 2H), 1.40 (s, 6H), 0.89 (d, 3H). Calc'd for C26H32FN4O4S [M+H]+: 515. found 515.

Provenance & Evidence