HRID385794

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(O)c1ccc(-c2cc(C(N)=O)c(N)s2)c(F)c1

HCID58216638

未命名化合物

HCID86646264

未命名化合物

PRODUCTS

生成物

结构：CC(C)C(O)C(c1cccc(Nc2sc(-c3ccc(C(C)(C)O)cc3F)cc2C(N)=O)n1)N1CCOCC1

HCID59525897

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as described in Example 1 using 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (150 mg, 0.510 mmol) and 1-(6-bromopyridin-2-yl)-3-methyl-1-morpholin-4-ylbutan-2-ol (168 mg, 0.51 mmol) as starting materials.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f7888ecc076f4d4ebc98f685a6d9aa87
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08367706B2
来源说明: uspto-grants-2013_02

反应 SMILES

[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:18])[CH3:17])=[CH:12][C:11]=2[F:20])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:22]1[N:27]=[C:26]([CH:28]([N:34]2[CH2:39][CH2:38][O:37][CH2:36][CH2:35]2)[CH:29]([OH:33])[CH:30]([CH3:32])[CH3:31])[CH:25]=[CH:24][CH:23]=1>>[F:20][C:11]1[CH:12]=[C:13]([C:16]([OH:19])([CH3:17])[CH3:18])[CH:14]=[CH:15][C:10]=1[C:4]1[S:3][C:2]([NH:1][C:22]2[CH:23]=[CH:24][CH:25]=[C:26]([CH:28]([N:34]3[CH2:39][CH2:38][O:37][CH2:36][CH2:35]3)[CH:29]([OH:33])[CH:30]([CH3:32])[CH3:31])[N:27]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1