Formic Acid → 1-(6-Bromopyridin-2-yl)-2-morpholin-4-ylethanol

Participants

Reaction Steps

To a solution of 1-(6-bromopyridin-2-yl)-2-morpholin-4-ylethanone (234 mg, 0.82 mmol) in methanol at 0° C. was added sodium borohydride (31.0 mg, 0.82 mmol). After 30 minutes, formic acid (0.1 mL) was added and then the reaction mixture was diluted with ethyl acetate (40 mL), saturated aqueous sodium bicarbonate (10 mL), and water (10 mL). The layers were separated and the organic layer was washed with brine (10 mL), dried over sodium sulfate, filtered, and concentrated to give the title compound.

Provenance & Evidence