2-Amino-5-(2-fluorophenyl)thiophene-3-carboxamide → HCID 59525634, compound

HRID 385798Notes

Reaction equation

HRID 385798 reaction equation
Br[C:2]1[N:7]=[C:6]([CH:8]([OH:16])[CH2:9][N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:5]=[CH:4][CH:3]=1.[NH2:17][C:18]1[S:19][C:20]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[F:32])=[CH:21][C:22]=1[C:23]([NH2:25])=[O:24]>>[F:32][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=1[C:20]1[S:19][C:18]([NH:17][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([CH:8]([OH:16])[CH2:9][N:10]3[CH2:15][CH2:14][O:13][CH2:12][CH2:11]3)[N:7]=2)=[C:22]([C:23]([NH2:25])=[O:24])[CH:21]=1

Participants

3

Reactant 2

HCID 99646972-Amino-5-(2-fluorophenyl)thiophene-3-carboxamideHCID 59526060HCID 59526060, compound

Product 1

HCID 59525634HCID 59525634, compound

Procedure

The title compound was prepared according to the general procedure in Example 1 using 1-(6-bromopyridin-2-yl)-2-morpholin-4-ylethanol (86 mg, 0.30 mmol) and 2-amino-5-(2-fluorophenyl)thiophene-3-carboxamide (72 mg, 0.31 mmol) as the starting materials.

Sources & evidence

ORD record
ord-deb86f841bd64b9ea30104451f2ee67a
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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