2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525681, compound

HRID 385800Notes

Reaction equation

HRID 385800 reaction equation
Br[C:2]1[N:7]=[C:6]([CH2:8][CH:9]([C:11]2[CH:12]=[N:13][N:14]([CH3:16])[CH:15]=2)[OH:10])[CH:5]=[CH:4][CH:3]=1.[NH2:17][C:18]1[S:19][C:20]([C:26]2[C:31]([F:32])=[CH:30][C:29]([C:33]([OH:36])([CH3:35])[CH3:34])=[CH:28][C:27]=2[F:37])=[CH:21][C:22]=1[C:23]([NH2:25])=[O:24]>>[F:37][C:27]1[CH:28]=[C:29]([C:33]([OH:36])([CH3:35])[CH3:34])[CH:30]=[C:31]([F:32])[C:26]=1[C:20]1[S:19][C:18]([NH:17][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([CH2:8][CH:9]([OH:10])[C:11]3[CH:12]=[N:13][N:14]([CH3:16])[CH:15]=3)[N:7]=2)=[C:22]([C:23]([NH2:25])=[O:24])[CH:21]=1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59525951HCID 59525951, compound

Product 1

HCID 59525681HCID 59525681, compound

Procedure

The title compound was prepared according to the general procedure in Example 1 using (2-(6-bromopyridin-2-yl)-1-(1-methyl-1H-pyrazol-4-yl)ethanol (0.090 g, 0.32 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.10 g, 0.32 mmol) as the starting materials.

Sources & evidence

ORD record
ord-d5afddd99fd74b2c9dc741e77920a010
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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