2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525641, compound

HRID 385806Notes

Reaction equation

HRID 385806 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:18])[CH3:17])=[CH:12][C:11]=2[F:20])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:22]1[N:27]=[C:26]([CH:28]([CH:30]2[CH2:35][CH2:34][S:33](=[O:37])(=[O:36])[CH2:32][CH2:31]2)[OH:29])[CH:25]=[CH:24][CH:23]=1>>[O:37]=[S:33]1(=[O:36])[CH2:34][CH2:35][CH:30]([CH:28]([OH:29])[C:26]2[N:27]=[C:22]([NH:1][C:2]3[S:3][C:4]([C:10]4[CH:15]=[CH:14][C:13]([C:16]([OH:19])([CH3:17])[CH3:18])=[CH:12][C:11]=4[F:20])=[CH:5][C:6]=3[C:7]([NH2:9])=[O:8])[CH:23]=[CH:24][CH:25]=2)[CH2:31][CH2:32]1

Participants

3

Reactant 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59525861HCID 59525861, compound

Product 1

HCID 59525641HCID 59525641, compound

Procedure

The title compound was prepared as described in Example 1 with 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.14 g, 0.47 mmol) and (6-bromopyridin-2-yl)(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methanol (0.15 g, 0.46 mmol) as the starting materials.

Sources & evidence

ORD record
ord-243d1baad38d46c8b45111ee0011c85b
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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