2-Amino-5-(2-fluorophenyl)thiophene-3-carboxamide → HCID 59525877, compound

HRID 385809Notes

Reaction equation

HRID 385809 reaction equation
Br[C:2]1[N:7]=[C:6]([CH:8]([OH:11])[CH2:9][OH:10])[CH:5]=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][C:15]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[F:27])=[CH:16][C:17]=1[C:18]([NH2:20])=[O:19]>>[OH:11][CH:8]([C:6]1[N:7]=[C:2]([NH:12][C:13]2[S:14][C:15]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[F:27])=[CH:16][C:17]=2[C:18]([NH2:20])=[O:19])[CH:3]=[CH:4][CH:5]=1)[CH2:9][OH:10]

Participants

3

Reactant 2

HCID 99646972-Amino-5-(2-fluorophenyl)thiophene-3-carboxamideHCID 595258991-(6-Bromopyridin-2-yl)ethane-1,2-diol

Product 1

HCID 59525877HCID 59525877, compound

Procedure

The title compound was prepared according to the general procedure in Example 1 using 1-(6-bromopyridin-2-yl)ethane-1,2-diol (71 mg, 0.33 mmol) and 2-amino-5-(2-fluorophenyl)thiophene-3-carboxamide (78 mg, 0.33 mmol) as the starting materials.

Sources & evidence

ORD record
ord-8c0de008a48f47d7936def9dfecf89de
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

Loading…